Hydrochloric Acid → Methyl 4-(2-oxopropyl)benzoate

HRID 580628

반응식

HRID 580628 반응식
S(S([O-])(=O)=O)([O-])(=O)=[O:2].[Na+].[Na+].[C:11]([C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22](=NO)[CH3:23])=[CH:17][CH:16]=1)([O:13][CH3:14])=[O:12].Cl>O.CO>[C:11]([C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22](=[O:2])[CH3:23])=[CH:17][CH:16]=1)([O:13][CH3:14])=[O:12]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 146045Sodium dithionateHCID 867397271-(4-Carbomethoxyphenyl)propan-2-one oxime

생성물 1

HCID 11137970Methyl 4-(2-oxopropyl)benzoate

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Sodium metabisulphate (131 g) in water (300 ml) was added to 1-(4-carbomethoxyphenyl)propan-2-one oxime (37.5 g) in methanol (200 ml) and the mixture refluxed for 6 hours. The reaction mixture was cooled, concentrated hydrochloric acid (100 ml) added, the mixture extracted with chloroform and the combined chloroform extracts washed with water followed by sodium bicarbonate solution. The chloroform layer was dried (MgSO4) and evaporated to give the title compound as an oil (bp 126°-129°/0.7 mm) which crystallised on standing, (mp 40°-47°). τ (CDCl3) 7.88 (3H, s), 6.28 (2H, s), 6.14 (3H, s), 2.77 (2H, d, J=8 Hz), 2,04 (2H, d, J=8 Hz).

후처리

  1. temperaturethe mixture refluxed for 6 hours
  2. temperatureThe reaction mixture was cooled
  3. extractionthe mixture extracted with chloroform
  4. washthe combined chloroform extracts washed with water
  5. dry with materialThe chloroform layer was dried (MgSO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-ace6e6a004ae49a58fec74cbc5e3bcce
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04753962

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