Chlorate ion → Quinolinic Acid

반응식

Cl([O-])(=O)=O.[N:5]1[C:14]2[C:9](=CC=CC=2)[CH:8]=[CH:7][C:6]=1[C:15]([O-:17])=[O:16].[Cu+2:18].N1C2C(=CC=CC=2)C=CC=1[C:29]([O-:31])=[O:30]>>[Cu:18].[N:5]1[CH:14]=[CH:9][CH:8]=[C:7]([C:29]([OH:31])=[O:30])[C:6]=1[C:15]([OH:17])=[O:16]

참가 물질

반응물 2

HCID 104770Chlorate ion2회

HCID 12554537Copper quinolinate

생성물 2

HCID 1066Quinolinic Acid

HCID 23978Copper

실험 절차

In another example of a preferred embodiment of the process, a sodium chlorate solution is added in small increments to a mixture of the other components, including copper oxide, which has been previously mixed and heated to reaction temperature (99°-101° C.). The acid concentration in the mixture is about 5 equivalents of acid per liter. The total chlorate addition will provide a chlorate molar excess of about 18% relative to the quinoline present. An exotherm becomes apparent after 6-8% of the chlorate has been added, and soon thereafter a suspension of copper quinolinate develops. Total chlorate addition is completed in 2-4 hours with total reaction time of 10-12 hours. The product, crude copper salt of pyridine-2,3-dicarboxylic acid, is isolated by filtration.