Water → 2-Bromo-4-(trifluoromethoxy)phenol

HRID 580836노트

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HRID 580836 반응식
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[Br:13]Br.ClCCl.O>C(Cl)(Cl)Cl>[Br:13][C:6]1[CH:5]=[C:4]([O:3][C:2]([F:11])([F:12])[F:1])[CH:9]=[CH:8][C:7]=1[OH:10]

참가 물질

6

반응물 4

HCID 962WaterHCID 6344DichloromethaneHCID 24408BromineHCID 70015p-(Trifluoromethoxy)phenol

생성물 1

HCID 215840902-Bromo-4-(trifluoromethoxy)phenol

시약·촉매·용매 1

HCID 6212Chloroform용매2회

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온도
0 °C

실험 절차

To a cooled (0° C.) solution of 4-trifluoromethoxyphenol (35.6 g, 0.2 mol) in chloroform (280 ml) was added dropwise a solution of bromine (32 g, 0.2 mol) in chloroform (50 ml). The solution was stirred at 0° C. for 1 hour and at room temperature for 2 hours. Dichloromethane (200 ml) and water (400 ml) ware added and the organic phase was washed further with water (400 ml), brine (200 ml) and dried (MgSO4). The solvent was removed and the residue was purified by distillation at reduced pressure to give the title compound. 1H NMR (250 MHz, CDCl3) δ 7.38 (1H, d, J=2.1 Hz), 7.13 (1H, dd, J=9.1, 2.1 Hz), 7.03 (1H, d, J=9.1 Hz), and 5.53 (1H, s).

후처리

  1. washthe organic phase was washed further with water (400 ml), brine (200 ml)
  2. dry with materialdried (MgSO4)
  3. customThe solvent was removed
  4. distillationthe residue was purified by distillation at reduced pressure

출처 및 근거

ORD 기록
ord-cc5e1f9aca214d949d3e24baa86dae86
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05919781

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