3-Chloroaniline → HCID 11629788, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].C(=O)([O-])[O-].[K+].[K+].[CH3:15][O:16][C:17](=[O:20])[CH2:18]Br.CCOC(C)=O>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][CH2:18][C:17]([O:16][CH3:15])=[O:20])[CH:6]=[CH:7][CH:8]=1참가 물질
6
반응 조건
- 온도
- 60 °C
실험 절차
To a solution of 3-chloroaniline and potassium carbonate (3 equiv.) in DMF is added methylbromoacetate (1.1 equiv.), and the reaction is stirred at 60° C. After complete reaction, the solution is poured into EtOAc and washed with water, sat. aq. NaHCO3 soln., and brine. The solution is dried (Na2SO4), filtered, and concentrated in vacuo. The resulting material is purified by silica gel chromatography to provide the titled compound.
후처리
- customAfter complete reaction
- washwashed with water, sat. aq. NaHCO3 soln
- dry with materialThe solution is dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe resulting material is purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-a725d08ce0c04d57bccbf93f0443fb94
- 출처 데이터셋
- uspto-grants-1999_07
- 특허 번호
- US05919785
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