Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide

HRID 58123

반응식

HRID 58123 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:11])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([NH:11][C:12](=[O:14])[CH3:13])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 663013,5-Dimethoxyaniline

생성물 1

HCID 702039N-(3,5-dimethoxyphenyl)acetamide수율 90,486%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 3,5-dimethoxy-phenylamine (20 g, 0.131 mol) in toluene (110 mL) was added acetic anhydride (14 g, 0.137 mmol) at room temperature. The resulting mixture was stirred for 18 hours at room temperature. PE (55 mL) was added, the precipitate was filtered and washed with PE (100 mL) to obtain the title compound (24.2 g, yield: 95%). 1H-NMR (400 MHz, CDCl3) δ 2.16 (s, 3H), 3.77 (s, 6H), 6.23 (s, 1H), 6.75 (s, 2H), 7.20 (s, 1H).

후처리

  1. additionPE (55 mL) was added
  2. filtrationthe precipitate was filtered
  3. washwashed with PE (100 mL)

출처 및 근거

ORD 기록
ord-7e9f9581dfb944339b040643ad69ba60
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434697B2

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