Methanol → Methyl 4-nitroanthranilate
반응식
[NH2:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:19]O>>[NH2:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:19])=[O:5]참가 물질
4
실험 절차
A mixture of 118.8 g of 2-amino-4-nitro-benzoic acid, 1000 ml of methanol and 120 ml of concentrated sulfuric acid is heated at the boiling point for 16 hours. The mixture is concentrated under reduced pressure, the residue is taken up in ethyl acetate and the mixture is washed with saturated NaHCO3 solution. After drying over Na2SO4, the organic phase is concentrated. 114.2 g (89%) of methyl 2-amino-4-nitro-benzoate are thus obtained with a melting point (m.p.) of 156-158° C.
후처리
- temperatureis heated at the boiling point for 16 hours
- concentrationThe mixture is concentrated under reduced pressure
- washthe mixture is washed with saturated NaHCO3 solution
- dry with materialAfter drying over Na2SO4
- concentrationthe organic phase is concentrated
출처 및 근거
- ORD 기록
- ord-4f8c35cb17de4c0ca3cb4158075d7987
- 출처 데이터셋
- uspto-grants-1999_07
- 특허 번호
- US05922646
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