Hydrochloric Acid → 2-{[[4-[3-(4-Benzylpiperazin-1-yl)propylthio]-3-methoxy-2-pyridinyl]-methyl]thio}-1H-benzimidazole trihydrochloride

HRID 581737노트

반응식

HRID 581737 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]2[NH:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[N:15]=2)[C:7]=1[O:23][CH3:24].[CH2:25]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[ClH:38]>>[ClH:1].[ClH:38].[ClH:1].[CH2:25]([N:32]1[CH2:37][CH2:36][N:35]([CH2:2][CH2:3][CH2:4][S:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]3[NH:18][C:17]4[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=4[N:15]=3)[C:7]=2[O:23][CH3:24])[CH2:34][CH2:33]1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 759941-BenzylpiperazineHCID 540544902-{[[4-(3-chloropropylthio)-3-methoxy-2-pyridinyl]methyl]thio}-1H-benzimidazole

생성물 1

HCID 867542022-{[[4-[3-(4-Benzylpiperazin-1-yl)propylthio]-3-methoxy-2-pyridinyl]-methyl]thio}-1H-benzimidazole trihydrochloride수율 59%

실험 절차

According to the procedure indicated in Examples 1), 3) and 6), reaction of 2-{[[4-(3-chloropropylthio)-3-methoxy-2-pyridinyl]methyl]thio}-1H-benzimidazole with N-benzylpiperazine and subsequent conversion into the hydrochloride gives the title compound; m.p. 180° C., dec.; colorless crystals; yield 59% of theory.

출처 및 근거

ORD 기록
ord-12b6f137c03b4614aaa0149065c8da2b
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922720

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