Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide

HRID 58174

반응식

HRID 58174 반응식
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1)[NH2:13]>C1(C)C=CC=CC=1.CCCCCC>[CH3:18][O:17][C:15]1[CH:14]=[C:12]([NH:13][C:1](=[O:3])[CH3:2])[CH:11]=[C:10]([O:9][CH3:8])[CH:16]=1

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 663013,5-Dimethoxyaniline

생성물 1

HCID 702039N-(3,5-dimethoxyphenyl)acetamide수율 98%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8058Hexane용매

실험 절차

Acetic anhydride (6.5 mL) was added slowly to a stirred solution of 3,5-dimethoxy aniline (10 g, 65.359 mmol) in toluene (50 mL) under argon atmosphere at room temperature and resulting reaction mixture was stirred for 15 h. After completion of the reaction, reaction was diluted with Hexane and resulted precipitate was collected by filtration and dried under vacuum to afford the title compound (12.5 g, 98% of yield) as a off-white solid. 1HNMR (CDCl3, 300 MHz): δ 7.38 (s, 1H), 6.75 (d, 2H), 6.23 (s, 1H), 3.76 (s, 6H), 2.15 (s, 3H); MS (ESI): 196.1 [M+H]+.

후처리

  1. customresulting
  2. customreaction mixture
  3. customAfter completion of the reaction, reaction
  4. customresulted precipitate
  5. filtrationwas collected by filtration
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-135f662ea86f44bab12e31be80d689b7
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434697B2

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