Benzoyl chloride, 3-nitro- → 3-Nitro-N-(3-pyridinylmethyl)benzamide

HRID 581754노트

반응식

HRID 581754 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])([O-:3])=[O:2].C(=O)(O)[O-].[Na+].[NH2:18][CH2:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1>C(OCC)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH:18][CH2:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)=[O:8])([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 8495Benzoyl chloride, 3-nitro-HCID 310183-PyridinemethanamineHCID 516892Sodium Bicarbonate

생성물 1

HCID 7434213-Nitro-N-(3-pyridinylmethyl)benzamide수율 46%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a stirred two-phase solution of 3-nitrobenzoyl chloride (9.3 g) in a mixture of diethyl ether (50 ml) and saturated sodium bicarbonate solution (50 ml) was added 3-aminomethylpyridine (5.4 g) in an ice-cooled bath. The mixture was stirred vigorously at ambient temperature for 30 minutes. The reaction mixture was filtered, and the resulting solid was washed with water. The solid was further solidified with diisopropyl alcohol-water to afford 3-nitro-N-(3-pyridylmethyl)benzamide (5.91 g) as a pale yellow amorphous solid.

후처리

  1. temperaturecooled bath
  2. filtrationThe reaction mixture was filtered
  3. washthe resulting solid was washed with water

출처 및 근거

ORD 기록
ord-f2eed9f4507345e593682fd9efd7097f
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922711

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