Pyridine → 2-(Cyclopent-3-en-1-yl)ethyl toluenesulfonate

HRID 581881

반응식

HRID 581881 반응식
[C:1]1(C)[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH:12]1([CH2:17][CH2:18][OH:19])[CH2:16][CH:15]=[CH:14][CH2:13]1.N1C=CC=C[CH:21]=1>>[C:3]1([CH3:21])[C:4]([S:7]([O:19][CH2:18][CH2:17][CH:12]2[CH2:16][CH:15]=[CH:14][CH2:13]2)(=[O:8])=[O:9])=[CH:5][CH:6]=[CH:1][CH:2]=1

참가 물질

4

반응물 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 157490023-Cyclopentene-1-ethanol

생성물 1

HCID 867542212-(Cyclopent-3-en-1-yl)ethyl toluenesulfonate수율 60.8%

실험 절차

A para-toluenesulfonylchloride (3.81 g, 20 mmol) was added to the pyridine (30 ml) solution of 2-(cyclopent-3-en-1-yl)ethyl alcohol (2.24 g, 20 mmol) and then the reaction mixture was stirred at room temperature for 2 hrs. After the removement of pyridine, the residue was extracted with dichloromethane, washed with 1N HCl, dried, filtered and separated by column chromatography to give a desirable product (3.24 g).

후처리

  1. extractionAfter the removement of pyridine, the residue was extracted with dichloromethane
  2. washwashed with 1N HCl
  3. customdried
  4. filtrationfiltered
  5. customseparated by column chromatography

출처 및 근거

ORD 기록
ord-33cf5353fbfa4e159987f8de76ce1c8d
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922727

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