Hydroxyamine hydrochloride → HCID 86754224, 화합물

HRID 581921노트

반응식

HRID 581921 반응식
[CH:1]([C:3]1[CH:23]=[CH:22][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][N:17]=4)[CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1)=O.[NH2:24][OH:25].Cl>>[CH:1](=[N:24][OH:25])[C:3]1[CH:23]=[CH:22][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][N:17]=4)[CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1

참가 물질

3

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 539508245-Formyl-1-(3-(4-pyrimidyl)phenyl)benzimidazole

생성물 1

HCID 86754224HCID 86754224, 화합물수율 76.1%

실험 절차

was synthesized as described in Example 22 using (62) (150 mg, 0.50 mmol) instead of (55) and NH2OH.HCl (100 mg, 1.5 mmol). The reaction gave (63) (120 mg, 76%).Mp. 220-221° C.

후처리

  1. customwas synthesized

출처 및 근거

ORD 기록
ord-8c9e31d3d8b744859d2ccf943ce9fc73
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922725

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