Sodium Hydroxide → 4-Bromo-2-nitroaniline

HRID 581949

반응식

HRID 581949 반응식
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:6]=1[N+:12]([O-:14])=[O:13])(=O)C.[OH-].[Na+]>C(COC)OC>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([NH2:4])=[C:6]([N+:12]([O-:14])=[O:13])[CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 136690N-(4-bromo-2-nitrophenyl)acetamide

생성물 1

HCID 701324-Bromo-2-nitroaniline

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

반응 조건

온도
80 °C

실험 절차

A mixture of 1d (3.5 g, 13.5 mmol), dimethoxyethane (100 ml) and aqueous sodium hydroxide (50 ml, 1 M) is heated to 80° C. for 1 hour. After cooling the mixture is poured into ice-water. The product is filtered off, washed with water and dried. Yield 2.77 g (94%). Mp 109-1 10° C.

후처리

  1. temperatureAfter cooling the mixture
  2. filtrationThe product is filtered off
  3. washwashed with water
  4. customdried
  5. customMp 109-1 10° C.

출처 및 근거

ORD 기록
ord-ce5c175808de4d54af57312909f4641a
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922724

연결된 노트

불러오는 중…