Sodium Hydroxide → 5-Bromo-6-methoxybenzo[b]thiophene-3-carboxylic acid

HRID 581982노트

반응식

HRID 581982 반응식
[Br:1][C:2]1[C:15]([O:16][CH3:17])=[CH:14][C:5]2[S:6][CH:7]=[C:8]([C:9]([O:11]CC)=[O:10])[C:4]=2[CH:3]=1.[OH-].[Na+]>C(O)C.O>[Br:1][C:2]1[C:15]([O:16][CH3:17])=[CH:14][C:5]2[S:6][CH:7]=[C:8]([C:9]([OH:11])=[O:10])[C:4]=2[CH:3]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 53817228Ethyl 5-bromo-6-methoxybenzo[b]thiophene-3-carboxylate

생성물 1

HCID 537810295-Bromo-6-methoxybenzo[b]thiophene-3-carboxylic acid수율 96.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Ethyl 5-bromo-6-methoxybenzo[b]thiophene-3-carboxylate (D4) (0.42 g, 0.0013 mole) in ethanol (20 ml) and water (5 ml) was treated with sodium hydroxide powder (0.14 g, 0.0035 mole). The reaction mixture was heated under reflux for 2 hours and stirred at ambient temperature for 16 hours. The solvent was removed in vacuo and the residue diluted with water (25 ml), acidified with 5N hydrochloric acid, extracted into ethyl acetate, dried (Na2SO4) and evaporated in vacuo to afford the title compound (0.36 g, 93%) as a beige solid.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 2 hours
  3. customThe solvent was removed in vacuo
  4. additionthe residue diluted with water (25 ml)
  5. extractionextracted into ethyl acetate
  6. dry with materialdried (Na2SO4)
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-212c164fe6a64f7fbed576362b4b2f64
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922733

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