HCID 53660198, 화합물 → 1H-Indole, 5-broMo-6-Methoxy-

HRID 581990노트

반응식

HRID 581990 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[N:7](S(C)(=O)=O)[CH:6]=[CH:5]2>[OH-].[Na+].C(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][CH:6]=[CH:5]2

참가 물질

4

반응물 1

HCID 53660198HCID 53660198, 화합물

생성물 1

HCID 534184371H-Indole, 5-broMo-6-Methoxy-수율 99.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

The 1-methylsulphonylindole (D19, 21.2 g, 69.7 mmol) was heated under reflux in a mixture of 10% aqueous sodium hydroxide solution (170 ml) and ethanol (1.0 L) for 1.5 h. The mixture was evaporated almost to dryness, and the residue was dissolved in ethyl acetate and washed with water. The organic phase was dried and evaporated to give the title compound (15.65 g, 99%), mp 110-111° C.

후처리

  1. customThe mixture was evaporated almost to dryness
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with water
  4. customThe organic phase was dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-30c79622ed794261a725e7ef08475ba7
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922733

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