Water → 3-(3-Fluoro-4-methoxyphenyl)propionic acid

HRID 582208노트

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HRID 582208 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O.[OH-].[K+]>C(O)C.Cl>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

참가 물질

6

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 22558762HCID 22558762, 화합물

생성물 1

HCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acid수율 96%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of ethyl 3-(3-fluoro-4-methoxyphenyl)propionate (29.1 g, 129 mmol) in ethanol(50 ml)-water(50 ml) was added potassium hydroxide (9.4 g, 167 mmol) and the mixture was stirred at 80° C. for 1 hour. After cooling, the reaction mixture was poured in diluted hydrochloric acid and the resulting crystals were recovered by filtration and washed with diethyl ether to provide the title compound (yield 24.4 g, 96%).

후처리

  1. temperatureAfter cooling
  2. filtrationthe resulting crystals were recovered by filtration
  3. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-092c0705c8a040189f7bc12497739e4b
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922771

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