Chloroform → Methyl 4-bromo-3-oxopentanoate

HRID 58234

반응식

HRID 58234 반응식
[Br:1]Br.C(Cl)(Cl)Cl.[O:7]=[C:8]([CH2:14][CH3:15])[CH2:9][C:10]([O:12][CH3:13])=[O:11]>>[Br:1][CH:14]([CH3:15])[C:8](=[O:7])[CH2:9][C:10]([O:12][CH3:13])=[O:11]

참가 물질

4

반응물 3

HCID 6212Chloroform2회HCID 24408BromineHCID 121699Methyl 3-oxovalerate

생성물 1

HCID 9815681Methyl 4-bromo-3-oxopentanoate

반응 조건

온도
0 °C

실험 절차

Under a nitrogen atmosphere, a solution of bromine (8.61 mL, 167 mmol) in chloroform (20 mL, 200 mmol) was added dropwise over a period of 2 h to a solution of 3-oxopentanoic acid, methyl ester (Aldrich, 21.0 mL, 167 mmol) in chloroform (147 mL, 1840 mmol), at 0° C. (ice bath). The reaction mixture was stirred for 30 min at 0° C. and then allowed to stand at room temperature overnight. While stirring, a stream of air was bubbled through the solution for 1 hour. After drying over sodium sulfate, the solvent was evaporated under reduced pressure leaving the desired compound.

후처리

  1. waitto stand at room temperature overnight
  2. stirringWhile stirring
  3. customa stream of air was bubbled through the solution for 1 hour
  4. dry with materialAfter drying over sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-86862d0fe81b4e928e2e6e241f99f422
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434746B2

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