4-Nitro-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid → 4-Amino-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid

HRID 582759

반응식

HRID 582759 반응식
[N+:1]([C:4]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[C:7]([C:14]([OH:16])=[O:15])=[CH:6][CH:5]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[C:7]([C:14]([OH:16])=[O:15])=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 222619794-Nitro-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

생성물 1

HCID 221117984-Amino-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

4-Nitro-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid is described in Chem. Pharm. Bull., 1984, 32, 3968. The hydrogenation of 1.48 g of this nitro derivative is performed in methanol in the presence of Raney® nickel. After 4 hours with stirring, the catalyst is filtered off, the mixture is evaporated to dryness and the residue is taken up with ether and filtered off to obtain 1 g of the expected product. m.p.=180° C. (dec.).

후처리

  1. filtrationthe catalyst is filtered off
  2. customthe mixture is evaporated to dryness
  3. filtrationfiltered off

출처 및 근거

ORD 기록
ord-20c3b9de4c004b7f8456b42e75dc37c6
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05925661

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