Ethyl chloroacetate → Ethyl ethoxyacetate

HRID 582806

반응식

HRID 582806 반응식
Cl[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[O-:8][CH2:9][CH3:10].[Na+]>C(O)C>[CH2:9]([O:8][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH3:10]

참가 물질

4

반응물 2

HCID 7751Ethyl chloroacetateHCID 2723922Sodium ethoxide

생성물 1

HCID 69955Ethyl ethoxyacetate수율 98.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of ethyl chloracetate (100 g, 99% pure, 0.81 mol) in ethanol is treated with ethanolic sodium ethoxide (282.9 g, 20.6% solution, 0.86 mole NaOC2H5) over a 1 hr period at 20° C.-30° C., heated at 40° C.-45° C. for 0.5 hr, cooled to room temperature, treated with diatomaceous earth, stirred for 0.25 hr and filtered. The filtercake is washed with ethanol. The combined filtrates are distilled to obtain the title product as a colorless liquid 75.78 g, 98.8% pure (71% yield), bp 87° C.-88° C./59 mmHg, identified by 13CNMR, 1HNMR and mass spectral analyses.

후처리

  1. temperatureheated at 40° C.-45° C. for 0.5 hr
  2. additiontreated with diatomaceous earth
  3. filtrationfiltered
  4. washThe filtercake is washed with ethanol
  5. distillationThe combined filtrates are distilled

출처 및 근거

ORD 기록
ord-bf0c80d3ebdd46919339dbf745980f16
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05925764

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