Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(methoxycarbonyl)-4-keto-D-proline methyl ester → N-(methoxycarbonyl)-cis-4-hydroxy-D-proline methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(methoxycarbonyl)-4-keto-D-proline methyl ester | HCID 11275680 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Platinum | HCID 23939 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(methoxycarbonyl)-cis-4-hydroxy-D-proline methyl ester | HCID 21310449 | — |
| 생성물 | N-(methoxycarbonyl)-trans-4-hydroxy-D-proline methyl ester | HCID 21310450 | — |
반응 단계
A 5.0 mL solution of 0.125 g of N-(methoxycarbonyl)-4-keto-D-proline methyl ester in ethyl acetate was mixed with 12.5 mg of 5% platinum on alumina under 70 psig of hydrogen at 25° C. After 18 h, the yields of N-(methoxycarbonyl)-cis-4-hydroxy-D-proline methyl ester and N-(methoxycarbonyl)-trans-4-hydroxy-D-proline methyl ester were 98.7% and 1.3%, respectively, with no N-(methoxycarbonyl)-4-keto-D-proline methyl ester remaining.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05928933 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-b27de7f916044eaf81ca0ee908401ded |
| 출처 메모 | uspto-grants-1999_07 |