Triethylamine → HCID 19826117, 화합물

HRID 583358노트

반응식

HRID 583358 반응식
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[CH3:2].C(N(CC)CC)C.[C:18](Cl)(=[O:21])[CH:19]=[CH2:20]>>[CH2:1]([N:3]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[C:18](=[O:21])[CH:19]=[CH2:20])[CH3:2]

참가 물질

4

반응물 3

HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 96681N-Ethylpyridine-4-methylamine

생성물 1

HCID 19826117HCID 19826117, 화합물수율 68.4%

실험 절차

To a 0° C. solution of 0.835 ml (6.0 mmol) of 4-(ethylaminomethyl) pyridine and 1.05 ml (7.5 mmol) of triethylamine in 10 ml dichloomethane, was dropwise added 0.406 ml (5.0 mmol) of acryloyl chloride. The reaction mixture was warmed to room temperature and stilred for 18 hr. The resulting nmxture was washed with water and brne, dried over MgSO4, filtered and concentrated in vacuo. The residue was chromatographed on silica gel with 3% MeOH/CH2Cl2 as the eluant to provide 651 mg (68%) of the desired product as a yellow gum. Electrospray Mass Spec 191(M+H).

후처리

  1. customTo a 0° C.
  2. washThe resulting nmxture was washed with water and brne
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue was chromatographed on silica gel with 3% MeOH/CH2Cl2 as the eluant

출처 및 근거

ORD 기록
ord-b9aa764d069a4be2aed42a96c1eef3ab
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05929097

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