Hydrochloric Acid → (S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-amino-propionylamino]-4-methyl-pentanoic acid methyl ester hydrogen chloride salt

HRID 58362노트

반응식

HRID 58362 반응식
[CH3:1][O:2][C:3](=[O:32])[C@@H:4]([NH:9][C:10](=[O:31])[C@@H:11]([NH:23]C(OC(C)(C)C)=O)[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]=[CH2:22])=[CH:15][CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[ClH:33]>O1CCOCC1>[ClH:33].[CH3:1][O:2][C:3](=[O:32])[C@@H:4]([NH:9][C:10](=[O:31])[C@@H:11]([NH2:23])[CH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH:21]=[CH2:22])=[CH:17][CH:18]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86650238(S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester

생성물 1

HCID 66847093(S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-amino-propionylamino]-4-methyl-pentanoic acid methyl ester hydrogen chloride salt

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Methyl ester 1 (4.00 g, 8.92 mmol) was dissolved in 4M HCl in 1,4-dioxane (20 mL). The resultant solution was stirred at rt for 18 h before being concentrated in vacuo to yield a white solid, 3.43 g, 100%.

후처리

  1. concentrationbefore being concentrated in vacuo
  2. customto yield a white solid, 3.43 g, 100%

출처 및 근거

ORD 기록
ord-80e86ca51fe94179817a5886ec0c88da
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434762B2

반응 노트

불러오는 중…