Acetone → HCID 21707621, 화합물

HRID 583630노트

반응식

HRID 583630 반응식
[CH3:1][C:2]12[CH2:7][CH:6]1[CH2:5][CH:4]([CH2:8][CH:9]1OCC[O:10]1)[C:3]2([CH3:15])[CH3:14].CC(C)=O.Cl>O>[CH3:1][C:2]12[CH2:7][CH:6]1[CH2:5][CH:4]([CH2:8][CH:9]=[O:10])[C:3]2([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 21707623HCID 21707623, 화합물

생성물 1

HCID 21707621HCID 21707621, 화합물수율 79%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 11.0 g (52 mmol) of 2-(1,2,2-trimethylbicyclo[3.1.0]hex-3-ylmethyl)-[1,3]-dioxolane, 80 ml of acetone, 40 ml of water, 1.5 ml of conc. hydrochloric acid and 10 g of silica gel was stirred at reflux for 4 hours. After filtration, the solution was diluted with diethyl ether, washed with water, dried (MgSO4) and evaporated in vacuo. Kugelrohr distillation of the residue gave 6.8 g (79% yield) of (1,2,2-trimethylbicyclo[3,1,0]hex-3-yl)ethanal.

후처리

  1. temperatureat reflux for 4 hours
  2. filtrationAfter filtration
  3. additionthe solution was diluted with diethyl ether
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo
  7. distillationKugelrohr distillation of the residue

출처 및 근거

ORD 기록
ord-15d7b2baadeb42a299af208321fa2a3a
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05929291

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