홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1,2-Dichloroethane → 4-[2-(Imidazol-2-yl)ethyl]benzoyl-2(S)-phenylsulfonylamino-beta-alanine tert-butyl ester acetate

HRID 583688
노트
인쇄 미리보기

반응식

HRID 583688 반응식
Cl.[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][CH2:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=1.Cl.[NH2:19][CH2:20][C@H:21]([NH:29][S:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:32])=[O:31])[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23].C1C=CC2N(O)N=NC=2C=1.CN1CCOCC1.C(Cl)CCl>CN(C=O)C>[C:13]([OH:15])(=[O:14])[CH3:12].[C:25]([O:24][C:22](=[O:23])[C@@H:21]([NH:29][S:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:32])=[O:31])[CH2:20][NH:19][C:13](=[O:15])[C:12]1[CH:11]=[CH:10][C:9]([CH2:8][CH2:7][C:3]2[NH:2][CH:6]=[CH:5][N:4]=2)=[CH:17][CH:16]=1)([CH3:28])([CH3:26])[CH3:27]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 111,2-DichloroethaneHCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 22853534(S)-3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester hydrochlorideHCID 676956464-[2-(Imidazol-2-yl)ethyl]benzoic acid hydrochloride

생성물 1

HCID 86754337
4-[2-(Imidazol-2-yl)ethyl]benzoyl-2(S)-phenylsulfonylamino-beta-alanine tert-butyl ester acetate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Acid 23-5 (ca 2 mmol), amine 2-1 (700 mg, 2.0 mmol), HOBT (324 mg, 2.4 mmol), and NMM (0.77 mL, 7.0 mmol) were combined in 10 mL DMF at -15°, then EDC (364 mg, 1.9 mmol) was added The mixture was warmed to RT, stirred overnight, then concentrated. Flash chromatography (silica, 4:1:1 CH2Cl2 /MeOH/HOAc) provided 23-6, Rf 0.22 (silica, 4:1:1 CH2Cl2 :MeOH:HOAc).

후처리

  1. concentrationconcentrated
  2. customFlash chromatography (silica, 4:1:1 CH2Cl2 /MeOH/HOAc) provided 23-6, Rf 0.22 (silica, 4:1:1 CH2Cl2 :MeOH:HOAc)

출처 및 근거

ORD 기록
ord-62989eaa1423487aa2cff4ee25f181b4
출처 데이터셋
uspto-grants-1999_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05929120

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트