2,2-Dibromopropane → HCID 178526667, 화합물

HRID 583722

반응식

HRID 583722 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH:12]([N:15]3[CH:19]=[CH:18][N:17]=[CH:16]3)[CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[Br:20][C:21](Br)([CH3:23])[CH3:22]>C(O)CCCC.CN(C=O)C>[Br-:20].[Br-:20].[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH:12]([N+:15]3[CH:19]=[CH:18][N:17]([CH2:22][CH2:21][CH2:23][N+:17]4[CH:18]=[CH:19][N:15]([CH:12]5[CH2:13][CH2:14][N:10]([C:7]6[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=6)[CH2:11]5)[CH:16]=4)[CH:16]=3)[CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 116582,2-DibromopropaneHCID 12116531HCID 12116531, 화합물

생성물 1

HCID 178526667HCID 178526667, 화합물수율 189.3%

시약·촉매·용매 1

HCID 86593149HCID 86593149, 화합물용매

반응 조건

온도
115 °C

실험 절차

3.5 g (0.0135 mol) of 1-[1-(4-nitrophenyl)pyrrolidin-3-yl]-1H-imidazole were heated to 100° C. in 12 ml of a pentanol/DMF mixture (50/50). 1 g (0.005 mol) of dibromopropane was added. The reaction medium was heated at 115° C. for 17 hours. The precipitate was filtered off while hot and washed with pentanol and then with ether. After draining by suction and drying the precipitate, 3.4 g of yellow powder (4) were obtained. 33% yield.

후처리

  1. filtrationThe precipitate was filtered off while hot and
  2. washwashed with pentanol
  3. customdrying the precipitate

출처 및 근거

ORD 기록
ord-387f92f2044842899763467dfed4b438
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06923835B2

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