Piperonyl alcohol → HCID 69693236, 화합물

HRID 583757노트

반응식

HRID 583757 반응식
C(N1[CH:12]=[CH:11]N=C1)(N1C=CN=C1)=O.[S:13]1[CH:17]=[C:16]([C:18]([OH:20])=[O:19])[CH:15]=[C:14]1[C:21]([OH:23])=[O:22].[CH2:24](O)[C:25]1[CH:33]=[CH:32][C:31]2[O:30][CH2:29][O:28][C:27]=2[CH:26]=1>>[O:30]1[C:31]2[CH:32]=[CH:33][C:25]([CH:24]([O:22][C:21]([C:14]3[S:13][CH:17]=[C:16]([C:18]([OH:20])=[O:19])[CH:15]=3)=[O:23])[C:12]3[CH:11]=[CH:26][C:27]4[O:28][CH2:29][O:30][C:31]=4[CH:32]=3)=[CH:26][C:27]=2[O:28][CH2:29]1

참가 물질

4

반응물 3

HCID 10322Piperonyl alcoholHCID 682631,1'-CarbonyldiimidazoleHCID 255851Thiophene-2,4-dicarboxylic acid

생성물 1

HCID 69693236HCID 69693236, 화합물수율 114.8%

실험 절차

The title compound was prepared according to the procedure described for Example 2 using carbonyldiimidazole (1.1 g, 6.8 mmol), 2,4-thiophene-dicarboxylic acid (0.5 g, 2.9 mmol) and piperonyl alcohol (0.45 g, 2.9 mmol). Acidification of the aqueous workup mixture with dilute hydrochloric acid prior to filtration afforded 0.71 g of thiophene-2,4-dicarboxylic acid di-1,3-benzodioxol-5-ylmethyl ester. Recrystallization of a sample from methanol followed by trituration in ethyl acetate then ether and drying gave product with a mp 164-165° C.

후처리

  1. customThe title compound was prepared
  2. filtrationAcidification of the aqueous workup mixture with dilute hydrochloric acid prior to filtration

출처 및 근거

ORD 기록
ord-1b9be2b1d26c426d8d139978aa64840f
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06924276B2

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