Sodium Carbonate → HCID 178503197, 화합물

HRID 584123

반응식

HRID 584123 반응식
Cl.[NH2:2][OH:3].C([O-])([O-])=O.[Na+].[Na+].[CH3:10][S:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=1>O.CO>[OH:3][NH:2][C:16](=[NH:17])[C:15]1[CH:18]=[CH:19][C:12]([S:11][CH3:10])=[CH:13][CH:14]=1

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 5909604-(Methylthio)benzonitrile

생성물 1

HCID 178503197HCID 178503197, 화합물수율 75%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Hydroxylamine hydrochloride (104 mg, 1.5 mmol) and Na2CO3 (80 mg, 0.75 mmol) were dissolved in 0.5 mL of water. A solution of 4-methylsulfanyl-benzonitrile (223 mg, 1.5 mmol) in 4 mL of methanol was added and the combined solution was stirred at RT for about 48 h. After removal of the solvent, the precipitate was washed with water, filtered and dried to give N-hydroxy-4-methylsulfanyl-benzamidine (203 mg, 75%) which was used without further purification.

후처리

  1. customAfter removal of the solvent
  2. washthe precipitate was washed with water
  3. filtrationfiltered
  4. customdried

출처 및 근거

ORD 기록
ord-039cdc46e35a4491b963e45525ae843a
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06924284B2

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