Imidazole → 1-Bromo-4-(tert-butyldiphenylsilyloxymethyl)-3-methylbenzene

HRID 584212노트

반응식

HRID 584212 반응식
[C:1]([Si:5](Cl)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([CH3:4])([CH3:3])[CH3:2].N1C=CN=C1.[Br:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][OH:30])=[C:27]([CH3:33])[CH:26]=1>>[Br:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][O:30][Si:5]([C:1]([CH3:4])([CH3:3])[CH3:2])([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[C:27]([CH3:33])[CH:26]=1

참가 물질

4

반응물 3

HCID 795ImidazoleHCID 94078tert-ButyldiphenylchlorosilaneHCID 22280088(4-Bromo-2-methylphenyl)methanol

생성물 1

HCID 223426891-Bromo-4-(tert-butyldiphenylsilyloxymethyl)-3-methylbenzene수율 98.2%

실험 절차

Tert-butylchlorodiphenylsilane (13.06 g) and imidazole (9.7 g) were added to a solution of 4-bromo-2-methylbenzyl alcohol (9.55 g) in N,N-dimethylfocmamide (80 ml) at 5° C. and the mixture was allowed to warm to room temperature, and stirred for 18 hours. The mixture was extracted with ethyl acetate and the extract was washed with water, dried over magnesium sulfate, and concentrated under reduced pressure to give 1-bromo-4-(tert-butyldiphenylsilyloxymethyl)-3-methylbenzene (20.5 g) as a colorless oil.

후처리

  1. extractionThe mixture was extracted with ethyl acetate
  2. washthe extract was washed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b2384f4a54d448f3aadee38ca3dfa9cf
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06924278B2

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