Methanesulfinic acid → HCID 9862981, 화합물

HRID 584663노트

반응식

HRID 584663 반응식
Cl[C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10][C:9]2[C:4](=[CH:5][C:6]([Cl:17])=[C:7]([Cl:16])[CH:8]=2)[N:3]=1.[CH3:18][S:19]([OH:21])=[O:20].[Na]>CN(C=O)C>[Cl:16][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[Cl:17])[N:3]=[C:2]([S:19]([CH3:18])(=[O:21])=[O:20])[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10]2

참가 물질

5

반응물 3

HCID 87251Methanesulfinic acidHCID 5360545SodiumHCID 223410732,6,7-Trichloro-3-(trifluoromethyl)quinoxaline

생성물 1

HCID 9862981HCID 9862981, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 2,6,7-trichloro-3-trifluoromethylquinoxaline (64 mg, 0.2 mmol) in DMF (1 ml) was added methanesulfinic acid, sodium salt (43 mg, 0.4 mmol). The reaction mixture was stirred at room temperature overnight, then it was partitioned between ethyl acetate and water. The organic layer was separated and concentrated to an oil. This oil was further purified by column chromatography (ethyl acetate:hexanes 1:3) to yield the title compound as a white solid.

후처리

  1. customit was partitioned between ethyl acetate and water
  2. customThe organic layer was separated
  3. concentrationconcentrated to an oil
  4. customThis oil was further purified by column chromatography (ethyl acetate:hexanes 1:3)

출처 및 근거

ORD 기록
ord-0550dabd66cb443ab3c91089aeceef56
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927214B1

반응 노트

불러오는 중…