Phosphorus tribromide → 2-Bromo-6,7-dichloro-3-trifluoromethylquinoxaline

HRID 584667노트

반응식

HRID 584667 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[NH:8][C:7](=O)[C:6]([C:14]([F:17])([F:16])[F:15])=[N:5]2.P(Br)(Br)[Br:19]>>[Br:19][C:7]1[C:6]([C:14]([F:17])([F:16])[F:15])=[N:5][C:4]2[C:9](=[CH:10][C:11]([Cl:12])=[C:2]([Cl:1])[CH:3]=2)[N:8]=1

참가 물질

3

반응물 2

HCID 24614Phosphorus tribromideHCID 27678326,7-Dichloro-3-(trifluoromethyl)quinoxalin-2(1H)-one

생성물 1

HCID 223411132-Bromo-6,7-dichloro-3-trifluoromethylquinoxaline

반응 조건

온도
140 °C

실험 절차

6,7-Dichloro-3-trifluoromethyl-1H-quinoxalin-2-one (500 mg, 1.8 mmol) was dissolved in phosphorus tribromide (2.0 ml), and the solution was heated at 140° C. for 16 hours. The reaction mixture was cooled to room temperature, before it was poured out on ice (100 g) and extracted with dichloromethane. The organic phase was separated and dried with anhydrous sodium sulphate, then taken to dryness by rotary evaporation to leave a pale brown powder.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature, before it
  2. additionwas poured out on ice (100 g)
  3. extractionextracted with dichloromethane
  4. customThe organic phase was separated
  5. dry with materialdried with anhydrous sodium sulphate
  6. customtaken to dryness by rotary evaporation
  7. customto leave a pale brown powder

출처 및 근거

ORD 기록
ord-dc8899de52194adc91c5541aac4ae9ef
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927214B1

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