Pyridine → 2-(4-Methoxybenzoyl)-2-(4-methoxyphenyl)hydrazinecarbothioamide

HRID 584731노트

반응식

HRID 584731 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH:10][C:11](=[S:13])[NH2:12])=[CH:5][CH:4]=1.[CH3:14][O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1.N1C=CC=CC=1>>[CH3:14][O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([N:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[NH:10][C:11](=[S:13])[NH2:12])=[O:21])=[CH:18][CH:17]=1

참가 물질

4

반응물 3

HCID 1049PyridineHCID 7477p-Anisoyl chlorideHCID 28261724-Methoxyphenylthiosemicarbazide

생성물 1

HCID 223415752-(4-Methoxybenzoyl)-2-(4-methoxyphenyl)hydrazinecarbothioamide수율 33%

실험 절차

A mixture of 2-(4-methoxyphenyl)hydrazinecarbothioamide (0.5 g, 2.53 mmol), 4-methoxybenzoyl chloride (541 mg, 3.17 mmol), and pyridine (0.256 mL, 3.17 mmol) intoluene (10 mL) was refluxed for 1 hour. After cooling, the solvent was removed under reduced pressure. diisopropyl ether and small amount of methanol was added to the residue and a generated precipitate was isolated by filtration, washed with methanol-diisopropyl ether, and dried in vacuo to give 2-(4-methoxybenzoyl)-2-(4-methoxyphenyl)hydrazinecarbothioamide (277 mg, 33% yield).

후처리

  1. temperaturewas refluxed for 1 hour
  2. temperatureAfter cooling
  3. customthe solvent was removed under reduced pressure
  4. additiondiisopropyl ether and small amount of methanol was added to the residue
  5. customa generated precipitate was isolated by filtration
  6. washwashed with methanol-diisopropyl ether
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-705c820ea4f24b96b6acafc6a0823867
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927230B2

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