4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 2-Ethanoyloxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid

HRID 584871

반응식

HRID 584871 반응식
[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[F:15][C:16]1[C:23]([F:24])=[C:22]([C:25]([F:28])([F:27])[F:26])[C:21]([F:29])=[C:20]([F:30])[C:17]=1[CH2:18]Br>[I-].C([N+](CCCC)(CCCC)CCCC)CCC.CN(C=O)C>[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([NH:14][CH2:18][C:17]2[C:20]([F:30])=[C:21]([F:29])[C:22]([C:25]([F:26])([F:28])[F:27])=[C:23]([F:24])[C:16]=2[F:15])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 1271374-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromideHCID 13140652Acetyl-5-aminosalicylic acid

생성물 1

HCID 99798272-Ethanoyloxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid수율 53%

시약·촉매·용매 2

HCID 67553Tetrabutylammonium Iodide촉매HCID 6228Dimethylformamide용매

실험 절차

According to the similar procedure in Synthesis Example 1, by using 2-ethanoyloxy-5-aminobenzoic acid (0.81 g, 4.10 mmole) which was prepared from Synthesis Example (14-3), DMF (15 ml), TEA (0.1 ml), tetrabutyl ammonium iodide (5 mg), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (1.02 ml, 6.15 mmole), 0.92 g (53.0% yield) of was obtained 2-ethanoyloxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid as a white solid.:

후처리

  1. customAccording to the similar procedure in Synthesis Example 1

출처 및 근거

ORD 기록
ord-7760add4fbfa43a68c265e933e246d81
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927303B2

연결된 노트

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