Triphenylphosphine → Methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate

HRID 585067노트

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HRID 585067 반응식
O[CH2:2][CH:3]([NH:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1)=[O:10])[C:4]([O:6][CH3:7])=[O:5].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>O1CCCC1>[F:18][C:17]([F:20])([F:19])[C:14]1[CH:15]=[CH:16][C:11]([C:9]2[O:10][CH2:2][CH:3]([C:4]([O:6][CH3:7])=[O:5])[N:8]=2)=[CH:12][CH:13]=1

참가 물질

5

반응물 3

HCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 22064268Methyl 3-hydroxy-2-{[4-(trifluoromethyl)phenyl]carbonylamino}propanoate

생성물 1

HCID 22064303Methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

To a solution of methyl 3-hydroxy-2-{[4-(trifluoromethyl)phenyl]-carbonylamino}propanoate (2.57 g, 8.83mmol) in tetrahydrofuran (30 ml) was added triphenylphosphine (2.55 g, 9.71 mmol). The mixture was cooled to 0° C., and diisopropylazodicarboxylate (1.91 ml, 9.71 mmol) was added slowly. The mixture was stirred at room temperature for 2 days. Solvent was removed from the filtrate under reduced pressure, and the residue was purified by column chromatography, to yield methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate, a compound of formula (14). C. Preparation of a Compound of Formula (15)

후처리

  1. customSolvent was removed from the filtrate under reduced pressure
  2. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-22b998f068094bc5b3685d02c7eca62a
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06930111B2

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