Water → {5-[4-(Trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-ol

HRID 585073노트

반응식

HRID 585073 반응식
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[C:11]([C:14](OCC)=[O:15])[CH:10]=2)=[CH:5][CH:4]=1.[BH4-].[Na+].O>C(O)C>[F:20][C:2]([F:1])([F:19])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:13][N:12]=[C:11]([CH2:14][OH:15])[CH:10]=2)=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 22064085Ethyl 5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

생성물 1

HCID 22064161{5-[4-(Trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-ol

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
0 °C

실험 절차

Ethyl 5-[4-(trifluoromethyl)phenyl]isoxazole-3-carboxylate (130 mg) was dissolved in ethanol (10 ml), cooled to 0° C., and sodium borohydride (26 mg) was added in portions to the stirred solution. The mixture was stirred at room temperature for 4 hours, then excess water added. Solvent was evaporated under reduced pressure, and the residue was purified by preparative thin layer chromatography, eluting with 5% methanol/ethyl acetate, to provide {5-[4-(trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-ol, a compound of formula (24).

후처리

  1. customSolvent was evaporated under reduced pressure
  2. customthe residue was purified by preparative thin layer chromatography
  3. washeluting with 5% methanol/ethyl acetate

출처 및 근거

ORD 기록
ord-acd12eab6f3041ce97aac3d6d7a3d28c
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06930111B2

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