Hydrochloric Acid → 2-Ethoxycarbonyl-2,2-difluoro-1-phenylethyl 1-adamantanecarboxylate

HRID 58517

반응식

HRID 58517 반응식
[F:1][C:2]([F:16])([CH:8]([OH:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:17]12([C:27](Cl)=[O:28])[CH2:26][CH:21]3[CH2:22][CH:23]([CH2:25][CH:19]([CH2:20]3)[CH2:18]1)[CH2:24]2.C(N(CC)CC)C.Cl>C(Cl)Cl>[CH2:6]([O:5][C:3]([C:2]([F:16])([F:1])[CH:8]([O:15][C:27]([C:17]12[CH2:26][CH:21]3[CH2:20][CH:19]([CH2:25][CH:23]([CH2:22]3)[CH2:24]1)[CH2:18]2)=[O:28])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:4])[CH3:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 989151-Adamantanecarbonyl chlorideHCID 11138943Ethyl 2,2-difluoro-3-hydroxy-3-phenylpropanoate

생성물 1

HCID 1179666922-Ethoxycarbonyl-2,2-difluoro-1-phenylethyl 1-adamantanecarboxylate수율 97.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Ethyl 2,2-difluoro-3-hydroxy-3-phenylpropionate acid (9 g) prepared in Synthesis Example 1-4 and 1-adamantanecarbonyl chloride (9.5 g) were dissolved in methylene chloride (60 g), and a mixed solution of triethyl amine (6 g), 4-dimethyl aminopyridine (0.5 g) and methylene chloride (20 g) was dropped into the obtained solution under ice cooling. After aging overnight, 5% by mass hydrochloric acid was added to the product and quenched, and then the reaction solution was washed with water, and concentrated. Methylisobutyl ketone was added to the concentrated solution, and was concentrated again to obtain a target compound, or 1-adamantane carboxylic acid 2-ethoxycarbonyl-2,2-difluoro-1-phenyl-ethyl ester (15 g) as a colorless oily matter (yield: 68%).

후처리

  1. customquenched
  2. washthe reaction solution was washed with water
  3. concentrationconcentrated
  4. additionMethylisobutyl ketone was added to the concentrated solution
  5. concentrationwas concentrated again

출처 및 근거

ORD 기록
ord-b559aa3f57f942a1bb5d1fd0236eb0b3
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09436083B2

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