Hydrochloric Acid → HCID 22340319, 화합물

HRID 585304노트

반응식

[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:14]C(=O)C)[CH:10]=2)[N:5]=1.Cl>>[ClH:2].[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:14])[CH:10]=2)[N:5]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 22340304HCID 22340304, 화합물

생성물 1

HCID 22340319HCID 22340319, 화합물수율 192.6%

반응 조건

온도: 100 °C

실험 절차

To the N-[2-(chloromethyl)-6-quinolinyl]acetamide hydrochloride (900 mg, 3.32 mmol) obtained in Reference Example 6 was added 5N hydrochloric acid (17 ml), and the mixture was stirred at 100° C. for 2 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was washed with tetrahydrofuran to obtain the titled compound (849 mg) as powders.

후처리

concentrationThe reaction solution was concentrated under reduced pressure
washthe resulting residue was washed with tetrahydrofuran

출처 및 근거

ORD 기록: ord-7e9601225fc44cf2886c0c71f3a0d6c6
출처 데이터셋: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06930185B2

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