N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide → 2-(1-Pyrrolidinylmethyl)-6-quinolinylamine

HRID 585305노트

반응식

HRID 585305 반응식
[N:1]1([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH:17]C(=O)C)[CH:13]=3)[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=3)[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 1

HCID 22340322N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide

생성물 1

HCID 119945322-(1-Pyrrolidinylmethyl)-6-quinolinylamine수율 97.9%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
110 °C

실험 절차

To the N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide (5.53 g, 20.5 mmol) obtained in 1) of Example 7 was added concentrated hydrochloric acid (100 ml), the mixture was stirred at 110° C. for 1 hour, and the solvent was distilled off under reduced pressure. To the resulting residue was added ethyl acetate, the mixture was washed with an aqueous potassium carbonate solution and an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain the titled compound (4.56 g) as a powder from ethyl acetate-hexane.

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionTo the resulting residue was added ethyl acetate
  3. washthe mixture was washed with an aqueous potassium carbonate solution
  4. dry with materialan aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-e9e2182d72664dcc9b3a40e108dcb3f6
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06930185B2

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