1,2,3,4-Tetrahydroquinoline → 1-(4-Ethoxy-3-methoxybenzoyl)-2-methyl-4-(1,2,3,4-tetrahydroquinolin-1-yl)-1,2,3,4-tetrahydroquinoline

HRID 585381

반응식

HRID 585381 반응식
[CH2:1]([O:3][C:4]1[CH:23]=[CH:22][C:7]([C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13](O)[CH2:12][CH:11]2[CH3:21])=[O:9])=[CH:6][C:5]=1[O:24][CH3:25])[CH3:2].[NH:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28][CH2:27]1>>[CH2:1]([O:3][C:4]1[CH:23]=[CH:22][C:7]([C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]([N:26]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29][CH2:28][CH2:27]3)[CH2:12][CH:11]2[CH3:21])=[O:9])=[CH:6][C:5]=1[O:24][CH3:25])[CH3:2]

참가 물질

3

반응물 2

HCID 694601,2,3,4-TetrahydroquinolineHCID 223392011-(4-Ethoxy-3-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol

생성물 1

HCID 223393291-(4-Ethoxy-3-methoxybenzoyl)-2-methyl-4-(1,2,3,4-tetrahydroquinolin-1-yl)-1,2,3,4-tetrahydroquinoline수율 36%

실험 절차

Starting with 1-(4-ethoxy-3-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol (600 mg, 1.76 mmol) prepared in Reference Example 19 and 1,2,3,4-tetrahydroquinoline (703 mg, 5.28 mmol), the same procedure as shown in Example 1 was repeated to give the titled compound (288 mg, yield: 36%) as a white crystal. (cis:trans=2:3)

출처 및 근거

ORD 기록
ord-faf165e5c7da4bdba3244903e829958d
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06930104B2

연결된 노트

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