Itaconic acid → 5-Oxo-1-phenylpyrrolidine-3-carboxylic acid
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8]=[C:9]([CH2:13][C:14](O)=[O:15])[C:10]([OH:12])=[O:11].[OH-].[Na+]>O>[O:15]=[C:14]1[N:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:8][CH:9]([C:10]([OH:12])=[O:11])[CH2:13]1참가 물질
5
반응 조건
- 온도
- 110 °C
실험 절차
A mixture of aniline (3.26 g; 34.68 mmol) and 2-methylenesuccinic acid (5.47 g; 41.62 mmol) in water (10 mL) was heated in a sealed tube at 110° C. for 30 hours. After cooling to room temperature, 6N NaOH (13 mL) was added and the resulting precipitate was filtered off. The filtrate was acidified with 6N hydrochloric acid to pH 1 and the resulting precipitate was filtered, washed with water, and dried to yield 6.92 g (97%) of 5-oxo-1-phenypyrrolidine-3-carboxylic acid as a white solid.
후처리
- temperatureAfter cooling to room temperature
- filtrationthe resulting precipitate was filtered off
- filtrationthe resulting precipitate was filtered
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-d68ca60354664ce887cd2a0f418b1a7e
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434722B2
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