Hexanenitrile, 5-oxo- → HCID 21927832, 화합물
반응식
O=[C:2]([CH3:8])[CH2:3][CH2:4][CH2:5][C:6]#[N:7].[NH2:9][C:10]1[C:15]([CH:16]=O)=[CH:14][CH:13]=[CH:12][N:11]=1>C(O)C>[CH3:8][C:2]1[C:3]([CH2:4][CH2:5][C:6]#[N:7])=[CH:16][C:15]2[C:10](=[N:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1참가 물질
4
실험 절차
A mixture of 5-oxo-hexanenitrile (5 mL, TCI-US), 2-amino-3-formylpyridine (7 g, J. Org. Chem. 1983, vol.48, p3401) and ethanol (100 mL) was heated to reflux for 12 hours. Following evaporation of the solvent, the residue was chromatographed (silica gel, ethyl acetate) to give 4-[1,8]naphthyridin-2-yl-butyronitirile and the title product as colorless solids. 1H (CDCl3) δ 2.29 (3H, s); 2.83 (2H, t); 3.18 (2H, t); 7.48 (1H, dd); 8.04 (1H, s); 8.20 (1H, dd); 9.03 (1H, dd). Step 2
후처리
- temperaturewas heated
- temperatureto reflux for 12 hours
- customevaporation of the solvent
- customthe residue was chromatographed (silica gel, ethyl acetate)
- customto give 4-[1,8]naphthyridin-2-yl-butyronitirile
출처 및 근거
- ORD 기록
- ord-760887f24401417490bba0073d70e238
- 출처 데이터셋
- uspto-grants-2005_08
- 특허 번호
- US06933304B2
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