O-Toluidine → 1-(2-Methylphenyl)-2-oxo-3-pyrrolidinecarboxylic acid

HRID 58581

반응식

HRID 58581 반응식
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[NH2:13][C:14]1[C:15]([CH3:20])=[CH:16][CH:17]=[CH:18][CH:19]=1>C(O)C>[O:11]=[C:4]1[CH:5]([C:8]([OH:9])=[O:10])[CH2:7][CH2:6][N:13]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20]

참가 물질

4

반응물 2

HCID 7242O-ToluidineHCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione

생성물 1

HCID 44054571-(2-Methylphenyl)-2-oxo-3-pyrrolidinecarboxylic acid수율 91%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g, 1.47 mmol) and o-toluidine (0.470 mL; 4.41 mmol) in ethanol (3 mL). 2-oxo-1-o-tolylpyrrolidine-3-carboxylic acid 0.292 g (91%) was obtained as a white film.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-53d1152f05f74e8bad11f9b10c4d6e93
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434722B2

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