Potassium Nitrate → 5-Bromo-8-nitroisoquinoline

HRID 585911

반응식

HRID 585911 반응식
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[N+:12]([O-])([O-:14])=[O:13].[K+]>[OH-].[NH4+]>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 7364875-Bromoisoquinoline

생성물 1

HCID 8169835-Bromo-8-nitroisoquinoline

시약·촉매·용매 1

HCID 14923Ammonium Hydroxide용매

실험 절차

The diethyl ether solution from Example 57A was treated with potassium nitrate (10.1 g, 100 mmol). After stirring for one hour, The mixture was poured onto ice and neutralized with concentrated ammonium hydroxide (˜300 ml). The crude product was collected by filtration, dried, and recrystalization from methanol to provide the title compound (8.83 g).

후처리

  1. filtrationThe crude product was collected by filtration
  2. customdried
  3. customrecrystalization from methanol

출처 및 근거

ORD 기록
ord-8378bd2b8abd47ef93fa966ae2e38faa
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06933311B2

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