2,4-Dichlorophenethylamine → N-[2-(2,4-dichlorophenyl)ethyl]-N'-1H-indol-4-ylurea

HRID 585952

반응식

HRID 585952 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][NH2:11].[N:12]([C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[CH:17]=[CH:18][NH:19]2)=[C:13]=[O:14]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][NH:11][C:13]([NH:12][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[CH:17]=[CH:18][NH:19]2)=[O:14]

참가 물질

3

반응물 2

HCID 1429382,4-DichlorophenethylamineHCID 220326444-isocyanato-1H-indole

생성물 1

HCID 9975018N-[2-(2,4-dichlorophenyl)ethyl]-N'-1H-indol-4-ylurea

실험 절차

2-(2,4-Dichlorophenyl)ethylamine (0.21 g, 1.1 mmol) and the product of Example 80A (0.16 g, 1. mmol) were treated as described in Example 80B to provide the title compound. mp 170° C.; 1H NMR (300 MHz, DMSO-d6) δ 2.90 (m, 2H), 3.31 (m, 2H), 6.47 (m, 2H), 6.93 (m, 2H), 7.23 (m, 1H), 7.40 (m, 2H), 7.60 (m, 2H), 8.15 (s, 1H), 11.02 (s, 1H). MS (DCI+) m/z 347 (M+H). Anal. Calcd. for C17H15N3Cl20: C, 58.63; H, 4.34; N, 12.07. Found: C, 58.49; H, 4.49; N, 12.38.

출처 및 근거

ORD 기록
ord-f0e02111fadd487abf37f38ced233cc6
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06933311B2

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