Nitric Acid → 2,4-Diisopropyl-1-nitrobenzene

HRID 586676

반응식

HRID 586676 반응식
[N+:1]([O-:4])(O)=[O:2].[CH:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([CH3:16])[CH3:15])[CH:9]=1)([CH3:7])[CH3:6]>C(O)(=O)C.C(OC(=O)C)(=O)C.O.CCCCCC>[CH:5]([C:8]1[CH:9]=[C:10]([CH:14]([CH3:16])[CH3:15])[CH:11]=[CH:12][C:13]=1[N+:1]([O-:4])=[O:2])([CH3:7])[CH3:6]

참가 물질

7

반응물 2

HCID 944Nitric AcidHCID 74501,3-Diisopropylbenzene

생성물 1

HCID 223357262,4-Diisopropyl-1-nitrobenzene수율 98%

시약·촉매·용매 4

HCID 176Acetic Acid용매HCID 962Water용매HCID 7918Acetic Anhydride용매HCID 8058Hexane용매

실험 절차

Nitric acid (70%) (15.6 g, 185 mmol) was added slowly to a solution of 1,3-di-iso-propyl-benzene (available from Aldrich) (20 g, 123 mmol) in acetic acid (50 mL) and acetic anhydride (50 mL) at 0° C. over 20 min. After stirring at room temperature for 1 hour, the reaction mixture was diluted with water (250 mL) and hexane (500 mL). The organic layer was then washed with with water (50 mL), saturated Na2CO3 (50 mL), dried (Na2SO4) and concentrated to give the title compound in a crude form (25 g, 98% yield) as a colorless oil:

후처리

  1. washThe organic layer was then washed with with water (50 mL), saturated Na2CO3 (50 mL)
  2. dry with materialdried (Na2SO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e4a5090f80d14d719bf6c304ea57d41b
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936636B2

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