Acetic Anhydride → HCID 10149094, 화합물

HRID 586752노트

반응식

HRID 586752 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.C(N(CC)CC)C.[NH2:15][C:16]1[N:24]=[C:23]2[C:19]([NH:20][CH:21]=[N:22]2)=[C:18]([Cl:25])[N:17]=1>C1(C)C=CC=CC=1>[C:5]([N:22]1[CH:21]=[N:20][C:19]2[C:23]1=[N:24][C:16]([NH2:15])=[N:17][C:18]=2[Cl:25])(=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 53603492-Amino-6-chloropurine

생성물 1

HCID 10149094HCID 10149094, 화합물수율 100%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

A mixture of 204.2 g (2.00 mol) of acetic anhydride, 202.4 g (2.00 mol) of triethylamine and 169.6 g (1.00 mol) of 2-amino-6-chloropurine was stirred at 80° C. for 1 hour. The resulting suspension was cooled at 25° C., and thereafter diluted with 400 mL of toluene, and the diluted solution was filtered. The resulting crystals were suspended in 300 mL of isopropanol, and the suspension was filtered again. The resulting crystals were dried at 60° C. under reduced pressure, to give 211.8 g of white powder of 9-acetyl-2-amino-6-chloropurine (yield 100%).

후처리

  1. temperatureThe resulting suspension was cooled at 25° C.
  2. filtrationthe diluted solution was filtered
  3. filtrationthe suspension was filtered again
  4. customThe resulting crystals were dried at 60° C. under reduced pressure

출처 및 근거

ORD 기록
ord-c52926e774bb404f88c5c021b7c45a74
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936713B2

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