Water → 5-fluoropyridine-2-carboxylic Acid

HRID 586802

반응식

HRID 586802 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:8])=[N:6][CH:7]=1.[Mn]([O-])(=O)(=O)=[O:10].[K+].[OH2:15]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=[O:15])=[N:6][CH:7]=1

참가 물질

4

반응물 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 27628635-Fluoro-2-methylpyridine

생성물 1

HCID 27628765-fluoropyridine-2-carboxylic Acid수율 28%

실험 절차

To water (100 ml) were added 5-fluoro-2-methylpyridine (J. Med. Chem., 32, 1970(1989): 2.2 g, 20 mmol) and potassium permanganate (19.1 g, 120 mmol), and heated under reflux for 4 hours. The reaction mixture was filtrated and the filtrate was concentrated, acidified with KHSO4, extracted with ethyl acetate and the extract was dried over Na2SO4. The solvent was evaporated to give the title compound (0.80 g; 28%).

후처리

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. filtrationThe reaction mixture was filtrated
  4. concentrationthe filtrate was concentrated
  5. extractionextracted with ethyl acetate
  6. dry with materialthe extract was dried over Na2SO4
  7. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-0679ce60ed2046d98a2dfdf025d884e4
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936736B2

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