3-Hydroxybenzaldehyde → 3-Propoxybenzaldehyde

HRID 587001

반응식

HRID 587001 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][CH3:19].O>CN(C=O)C>[CH2:17]([O:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6])[CH2:18][CH3:19]

참가 물질

6

반응물 4

HCID 1013-HydroxybenzaldehydeHCID 962WaterHCID 78401-BromopropaneHCID 11430Potassium Carbonate

생성물 1

HCID 27604693-Propoxybenzaldehyde수율 99.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 3-hydroxybenzaldehyde (10.0 g) in DMF (120 ml) were added potassium carbonate (15.8 g) and 1-bromopropane (12.1 g), and the mixture was stirred under nitrogen atmosphere at room temperature overnight. Then, water was added to the mixture, which was extracted with ethyl acetate and washed with 1N sodium hydroxide solution twice, with water three times and with saturated brine once. After dried with magnesium sulfate, the solvent was evaporated under reduced pressure to give 3-propoxybenzaldehyde (13.4 g) as colorless liquid.

후처리

  1. extractionwas extracted with ethyl acetate
  2. washwashed with 1N sodium hydroxide solution twice
  3. dry with materialAfter dried with magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e532573e9813427585e1ab5d71970579
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936602B1

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