Benzenesulfonamide, 3-amino- → 3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenesulfonamide

반응식

[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11](CS(N)(=O)=O)[CH:12]=[CH:13][CH:14]=2)[N:3]=1.ClC1N=C(Cl)N=CN=1.NC1C=C([S:35]([NH2:38])(=[O:37])=[O:36])C=CC=1>>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([S:35]([NH2:38])(=[O:37])=[O:36])[CH:12]=[CH:13][CH:14]=2)[N:3]=1

참가 물질

반응물 3

HCID 7377Benzenesulfonamide, 3-amino-

HCID 178102,4-Dichloro-1,3,5-triazine

HCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

생성물 1

HCID 866798233-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenesulfonamide수율 35%

실험 절차

A2 was prepared following the general procedure reported for A1 using 2,4-dichloro-1,3,5-triazine and 3-aminobenzenesulfonamide as reacting agents. The crude product was purified by flash chromatography on silica gel (cHex/EtOAc=20:1 to 1:20) to yield the desired product A2 as a white solid (35%). 1H NMR (400 MHz, d6-DMSO, 300K) δ 7.41 (s, 2H), 7.59 (m, 2H), 7.85 (d, J=6.9 Hz, 1H), 8.21 (br.s, 1H), 8.69 (s, 1H), 11.02 (s, 1H). MS (ES) C9H8ClN5O2S requires: 285. found: 286 (M+H)+.