Methanol → Benzoic acid, 5-chloro-2-hydroxy-, methyl ester

HRID 5874

반응식

HRID 5874 반응식
S(Cl)(Cl)=O.[Cl:5][C:6]1[CH:14]=[C:10]([C:11]([OH:13])=[O:12])[C:9]([OH:15])=[CH:8][CH:7]=1.[CH3:16]O>>[Cl:5][C:6]1[CH:14]=[C:10]([C:11]([O:13][CH3:16])=[O:12])[C:9]([OH:15])=[CH:8][CH:7]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 94475-Chlorosalicylic AcidHCID 24386Thionyl Chloride

생성물 1

HCID 77684Benzoic acid, 5-chloro-2-hydroxy-, methyl ester

실험 절차

To a cold solution of 100 ml methanol is slowly added 100 ml thionyl chloride followed by 30 g of 5-chlorosalicylic acid. This is then refluxed overnight, the solvent removed and the residue dissolved in ether. The ether is washed with a sodium bicarbonate solution, water, dried over magnesium sulfate and evaporated to dryness to obtain methyl 5-chlorosalicylate which is used directly in the next step.

후처리

  1. temperatureThis is then refluxed overnight
  2. customthe solvent removed
  3. dissolutionthe residue dissolved in ether
  4. washThe ether is washed with a sodium bicarbonate solution, water
  5. dry with materialdried over magnesium sulfate
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-2e45f94245eb45bca513a2ee7f3e24bf
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05246942

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