Hydrochloric Acid → Methyl 4-amino-5-chloro-2-methoxybenzoate

HRID 5877

반응식

HRID 5877 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl.[CH3:15]O>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:15])=[O:6]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 816264-Amino-5-chloro-2-methoxybenzoic acid

생성물 1

HCID 700493Methyl 4-amino-5-chloro-2-methoxybenzoate

실험 절차

To a solution of 50g of 2-methoxy-4-amino-5-chlorobenzoic acid in 500 ml of methanol is added HCl gas until all the material dissolves. Stirring is continued overnight, the solvent removed, ether added, filtered, dried over magnesium sulfate and evaporated to dryness to obtain methyl 2-methoxy-4-amino-5-chlorobenzoate which is used directly in the next step.

후처리

  1. dissolutiondissolves
  2. customthe solvent removed
  3. additionether added
  4. filtrationfiltered
  5. dry with materialdried over magnesium sulfate
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-1eb26c95049e45f5a0d34f4298931c2b
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05246942

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