Phthalic Anhydride → HCID 11032835, 화합물

HRID 588120노트

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HRID 588120 반응식
[NH2:1][C@@H:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][OH:4].[C:11]1(=O)[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13](=[O:20])[O:12]1>C(Cl)Cl>[OH:4][CH2:3][C@@H:2]([N:1]1[C:11](=[O:12])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:20])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 6811Phthalic AnhydrideHCID 1347972-Amino-2-phenylethan-1-ol

생성물 1

HCID 11032835HCID 11032835, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
150 °C

실험 절차

(S)-2-amino-2-phenylethanol (2 g, 14.58 mmol) and isobenzofuran-1,3-dione (2.267 g, 15.31 mmol) were combined in a 20 mL microwave tube, sealed and heated to 150° C. for 6 hrs. The tube was cooled to ambient temperature, dilluted with DCM, loaded directly onto a 50 g SNAP column and purified 10-60% hexane/EtOAc to provide (S)-2-(2-hydroxy-1-phenylethyl)isoindoline-1,3-dione. MS: [M+H]+ m/z 268.

후처리

  1. customsealed
  2. temperatureThe tube was cooled to ambient temperature
  3. custompurified 10-60% hexane/EtOAc

출처 및 근거

ORD 기록
ord-d637004903034c39afe4412ef5198d42
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09226922B2

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